Antibacterial Activity Test of Mahkota Dewa Fruit (Phaleria macrocarpa) Extract against Escherichia Coli Bacteria

Exposure to Escherichia coli during pregnancy may cause serious problems such as anemia, premature birth and an increased risk of inflammation the lining brain in fetus. Mahkota Dewa (Phaleria macrocarpa) is a medicinal plant that widely known used treat allergies chronic diseases. One compounds contained flavonoids. There certain mechanism action flavonoids inhibiting bacteria namely by damaging cytoplasmic cell wall bacteria. This study aims analyze antibacterial properties various flavonoid concentrations fruit extract against through laboratory experimental design testing antimicrobial potency well method, 10percent, 20percent, 40percent, 60percent, 80percent 100percent. Statistical analysis using One-Way Anova Test showed significant difference between changes concentration inhibition zones towards growth (p less than 0.05). Pearson correlation test very strong relationship with positive direction (r equals 0.874) which indicated higher dewa extract, stronger effect. Based on findings, it can be concluded had potential Coli vitro.